Fulminant amoebic colitis following loperamide use.

Alastair McGregor; Michael Brown; Khin Thway; Stephen G Wright; (2007) Fulminant amoebic colitis following loperamide use. Journal of travel medicine, 14 (1). pp. 61-62. ISSN 1195-1982 DOI: 10.1111/j.1708-8305.2006.00096.x
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Toxic megacolon is a rare consequence of infection with Entamoeba histolytica. We present such a patient in whom the course of disease may have been influenced by heavy loperamide use. Loperamide and other anti-motility agents have been implicated previously in the pathogenesis of toxic megacolon in patients with infectious gastroenteritis.

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