Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?

Andrew Vallely; Lisa Vallely; John Changalucha; Brian Greenwood

; Daniel Chandramohan

; (2007) Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed? Malaria journal, 6 (1). 16-. ISSN 1475-2875 DOI: 10.1186/1475-2875-6-16

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Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials.

Item Type	Article
Keywords	UNCOMPLICATED FALCIPARUM-MALARIA, PLUS SULFADOXINE-PYRIMETHAMINE, RANDOMIZED CONTROLLED-TRIAL, SUB-SAHARAN AFRICA, RESISTANT, PLASMODIUM-FALCIPARUM, SEXUALLY-TRANSMITTED INFECTIONS, MILLENNIUM, DEVELOPMENT GOALS, COST-EFFECTIVENESS ANALYSIS, IN-VITRO ACTIVITIES, ANTIMALARIAL-DRUGS, Africa, Antimalarials, pharmacology, therapeutic use, Clinical Trials, Phase II, Clinical Trials, Phase III, Disease Transmission, Horizontal, prevention & control, Drug Resistance, Female, Humans, Malaria, Falciparum, drug therapy, prevention & control, transmission, Pregnancy, Pregnancy Complications, Parasitic, drug therapy
ISI	244743000001