In the era of systematic reviews, does the size of an individual trial still matter.

Gordon HGuyatt; Edward JMills; Diana Elbourne ORCID logo; (2008) In the era of systematic reviews, does the size of an individual trial still matter. PLoS medicine, 5 (1). e4-. ISSN 1549-1277 DOI: 10.1371/journal.pmed.0050004
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Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews-and the fact that individual clinical trials rarely provide definitive answers to a clinical research question-some commentators question whether the sample size calculation for an individual trial still matters. Others point out that small trials can still be potentially misleading.
Item Type Article
ISI 254928700002

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