Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum.

Albert WW Van Wyk; Karina M Zuck; Tawnya C McKee; (2011) Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum. Journal of natural products, 74 (5). pp. 1275-1280. ISSN 0163-3864 DOI: 10.1021/np1006795
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Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.

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