Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Emma Jaeger;
Emily Webb 
;
Kimberley Howarth;
Luis Carvajal-Carmona;
Andrew Rowan;
Peter Broderick;
Axel Walther;
Sarah Spain;
Alan Pittman;
Zoe Kemp;
+25 more...
Kate Sullivan;
Karl Heinimann;
Steven Lubbe;
Enric Domingo;
Ella Barclay;
Lynn Martin;
Maggie Gorman;
Ian Chandler;
Jayaram Vijayakrishnan;
Wendy Wood;
Elli Papaemmanuil;
Steven Penegar;
Mobshra Qureshi;
CORGI Consortium;
Susan Farrington;
Albert Tenesa;
Jean-Baptiste Cazier;
David Kerr;
Richard Gray;
Julian Peto ;
Malcolm Dunlop;
Harry Campbell;
Huw Thomas;
Richard Houlston;
Ian Tomlinson;
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature genetics, 40 (1).
pp. 26-28.
ISSN 1061-4036
DOI: 10.1038/ng.2007.41
;
Kimberley Howarth;
Luis Carvajal-Carmona;
Andrew Rowan;
Peter Broderick;
Axel Walther;
Sarah Spain;
Alan Pittman;
Zoe Kemp;
+25 more...
Kate Sullivan;
Karl Heinimann;
Steven Lubbe;
Enric Domingo;
Ella Barclay;
Lynn Martin;
Maggie Gorman;
Ian Chandler;
Jayaram Vijayakrishnan;
Wendy Wood;
Elli Papaemmanuil;
Steven Penegar;
Mobshra Qureshi;
CORGI Consortium;
Susan Farrington;
Albert Tenesa;
Jean-Baptiste Cazier;
David Kerr;
Richard Gray;
Julian Peto ;
Malcolm Dunlop;
Harry Campbell;
Huw Thomas;
Richard Houlston;
Ian Tomlinson;
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature genetics, 40 (1).
pp. 26-28.
ISSN 1061-4036
DOI: 10.1038/ng.2007.41
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
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