ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology.

KNCouper; WChen; KMHouston; WHarnett; LLJohnson; (2005) ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology. Parasite immunology, 27 (4). pp. 147-150. ISSN 0141-9838 DOI: 10.1111/j.1365-3024.2005.00755.x

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ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology.

Item Type	Article
ISI	229280900006

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