ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology.
KN Couper;
W Chen;
KM Houston;
W Harnett;
LL Johnson;
(2005)
ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology.
Parasite immunology, 27 (4).
pp. 147-150.
ISSN 0141-9838
DOI: 10.1111/j.1365-3024.2005.00755.x
ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology.
| Item Type | Article |
|---|---|
| ISI | 229280900006 |