Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.
Krishnan Bhaskaran ;
DeenanPillay;
A SarahWalker;
MartinFisher;
DavidHawkins;
RichardGilson;
KenMcLean;
KholoudPorter;
UK Register of HIV Seroconverters;
(2004)
Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.
AIDS (London, England), 18 (10).
pp. 1471-1473.
ISSN 0269-9370
DOI: 10.1097/01.aids.0000131341.45795.33
Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.
Item Type | Article |
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Keywords | Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes/ immunology/virology, Cohort Studies, Drug Resistance, Viral/ immunology, Female, HIV Infections/ drug therapy, HIV Seropositivity/immunology, Humans, Lymphopenia/virology, Male, Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, immunology, virology, Cohort Studies, Drug Resistance, Viral, immunology, Female, HIV Infections, drug therapy, HIV Seropositivity, immunology, Humans, Lymphopenia, virology, Male |
ISI | 222641500016 |
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ORCID: https://orcid.org/0000-0001-5364-8757