Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest
Andrew Tsotinis;
Ioannis Papanastasiou;
George B. Foscolos;
Judit Ol�;
Judit Ov�i;
S Radhika Prathalingam;
John M. Kelly;
(2008)
Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest.
Heterocycles, 75 (8).
p. 2043.
ISSN 0385-5414
DOI: 10.3987/com-08-11377
New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity. © 2008 The Japan Institute of Heterocyclic Chemistry.
| Item Type | Article |
|---|---|
| ISI | 259131300016 |