Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest

New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity. © 2008 The Japan Institute of Heterocyclic Chemistry.