Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
;
Julian Peto ;
Michael R Stratton;
Nazneen Rahman;
Kevin Jacobs;
Ross Prentice;
Garnet L Anderson;
Aleksandar Rajkovic;
J David Curb;
Regina G Ziegler;
Christine D Berg;
Saundra S Buys;
Catherine A McCarty;
Heather Spencer Feigelson;
Eugenia E Calle;
Michael J Thun;
W Ryan Diver;
Stig Bojesen;
Børge G Nordestgaard;
Henrik Flyger;
Thilo Dörk;
Peter Schürmann;
Peter Hillemanns;
Johann H Karstens;
Natalia V Bogdanova;
Natalia N Antonenkova;
Iosif V Zalutsky;
Marina Bermisheva;
Sardana Fedorova;
Elza Khusnutdinova;
SEARCH;
Daehee Kang;
Keun-Young Yoo;
Dong Young Noh;
Sei-Hyun Ahn;
Peter Devilee;
Christi J van Asperen;
RAEM Tollenaar;
Caroline Seynaeve;
Montserrat Garcia-Closas;
Jolanta Lissowska;
Louise Brinton;
Beata Peplonska;
Heli Nevanlinna;
Tuomas Heikkinen;
Kristiina Aittomäki;
Carl Blomqvist;
John L Hopper;
Melissa C Southey;
Letitia Smith;
Amanda B Spurdle;
Marjanka K Schmidt;
Annegien Broeks;
Richard R van Hien;
Sten Cornelissen;
Roger L Milne;
Gloria Ribas;
Anna González-Neira;
Javier Benitez;
Rita K Schmutzler;
Barbara Burwinkel;
Claus R Bartram;
Alfons Meindl;
Hiltrud Brauch;
Christina Justenhoven;
Ute Hamann;
GENICA Consortium;
Jenny Chang-Claude;
Rebecca Hein;
Shan Wang-Gohrke;
Annika Lindblom;
Sara Margolin;
Arto Mannermaa;
Veli-Matti Kosma;
Vesa Kataja;
Janet E Olson;
Xianshu Wang;
Zachary Fredericksen;
Graham G Giles;
Gianluca Severi;
Laura Baglietto;
Dallas R English;
Susan E Hankinson;
David G Cox;
Peter Kraft;
Lars J Vatten;
Kristian Hveem;
Merethe Kumle;
Alice Sigurdson;
Michele Doody;
Parveen Bhatti;
Bruce H Alexander;
Maartje J Hooning;
Ans MW van den Ouweland;
Rogier A Oldenburg;
Mieke Schutte;
Per Hall;
Kamila Czene;
Jianjun Liu;
Yuqing Li;
Angela Cox;
Graeme Elliott;
Ian Brock;
Malcolm WR Reed;
Chen-Yang Shen;
Jyh-Cherng Yu;
Giu-Cheng Hsu;
Shou-Tung Chen;
Hoda Anton-Culver;
Argyrios Ziogas;
Irene L Andrulis;
Julia A Knight;
kConFab;
Australian Ovarian Cancer Study Group;
Jonathan Beesley;
Ellen L Goode;
Fergus Couch;
Georgia Chenevix-Trench;
Robert N Hoover;
Bruce AJ Ponder;
David J Hunter;
Paul DP Pharoah;
Alison M Dunning;
Stephen J Chanock;
Douglas F Easton;
(2009)
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Nature genetics, 41 (5).
pp. 585-590.
ISSN 1061-4036
DOI: 10.1038/ng.354
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.