Effectiveness of BA.1- and BA.4/BA.5-containing bivalent COVID-19 mRNA vaccines against symptomatic SARS-CoV-2 infection during the BA.5-dominant period in Japan

Takeshi Arashiro ORCID logo; YuzoArima; JinKuramochi; HirokazuMuraoka; AkihiroSato; KumiChubachi; AtsushiYanai; HirokoArioka; YukiUehara; GeneiIhara; +22 more... YasuyukiKato; NaokiYanagisawa; AkihiroUeda; Hideaki Kato ORCID logo; HideakiOka; YusukeNishida; YukiNidaira; Takahiro Asami ORCID logo; TorahikoJinta; AkiraNakamura; KunihiroOba; DaisukeTaniyama; KeiYamamoto; KatsushiTanaka; KankuroUeshima; TetsujiFuwa; AshleyStucky; TadakiSuzuki; Chris Smith ORCID logo; MartinHibberd; Koya Ariyoshi ORCID logo; MotoiSuzuki; (2023) Effectiveness of BA.1- and BA.4/BA.5-containing bivalent COVID-19 mRNA vaccines against symptomatic SARS-CoV-2 infection during the BA.5-dominant period in Japan. Open forum infectious diseases. ISSN 2328-8957 DOI: 10.1093/ofid/ofad240
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In this multi-center prospective test-negative case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent COVID-19 mRNA vaccines against symptomatic infection during the BA.5-dominant period was high compared to no vaccination (65% and 76%) and moderate compared to monovalent vaccines administered over half a year before (46% combined).



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