A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection.

Clara Calvert ORCID logo; Jade Carruthers; Cheryl Denny ORCID logo; Jack Donaghy; Sam Hillman; Lisa EM Hopcroft ORCID logo; Leanne Hopkins ORCID logo; Anna Goulding ORCID logo; Laura Lindsay; Terry McLaughlin; +18 more... Emily Moore ORCID logo; Jiafeng Pan; Bob Taylor ORCID logo; Fatima Almaghrabi; Bonnie Auyeung ORCID logo; Krishnan Bhaskaran ORCID logo; Cheryl L Gibbons; Srinivasa Vittal Katikireddi ORCID logo; Colin McCowan; Josie Murray; Maureen O'Leary; Lewis D Ritchie; Syed Ahmar Shah ORCID logo; Colin R Simpson ORCID logo; Chris Robertson; Aziz Sheikh ORCID logo; Sarah J Stock ORCID logo; Rachael Wood; (2022) A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection. Nature communications, 13 (1). 6124-. ISSN 2041-1723 DOI: 10.1038/s41467-022-33937-y
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Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.


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