Examining the Use of HIV Self-Testing to Support PrEP Delivery: a Systematic Literature Review.

Catherine Kiptinness; Alexandra P Kuo; Adriana M Reedy; Cheryl C Johnson ORCID logo; Kenneth Ngure; Anjuli D Wagner; Katrina F Ortblad; (2022) Examining the Use of HIV Self-Testing to Support PrEP Delivery: a Systematic Literature Review. Current HIV/AIDS Reports, 19 (5). pp. 394-408. ISSN 1548-3568 DOI: 10.1007/s11904-022-00617-x
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PURPOSE OF REVIEW: HIV self-testing (HIVST) has the potential to expand access to and uptake of HIV pre-exposure prophylaxis (PrEP) delivery. We conducted a systematic literature review to understand the evidence on HIVST use for PrEP delivery. RECENT FINDINGS: After screening 1055 records, we included eight: three randomized trials and five values and preferences studies. None measured PrEP initiation. Most studies occurred in Sub-Saharan Africa (7/8) and included different populations. One trial found that HIVST use between quarterly clinic visits as part of an adherence package with biofeedback slightly increased adherence; the other two trials found that HIVST use between or in lieu of quarterly clinic visits had no significant or non-inferior effects on adherence. HIVST to support PrEP delivery was acceptable, feasible, and preferred. HIVST use for PrEP continuation largely resulted in similar outcomes to standard-of-care delivery and was perceived acceptable and feasible. Further research is needed to optimize HIVST use within PrEP programming.


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