Human Herpesvirus-6 Detection in Cerebrospinal Fluid on the BioFire FilmArray Meningitis/Encephalitis Panel in a High Human Immunodeficiency Virus-Prevalence African Setting.

James Milburn ORCID logo; Kwana Lechiile; Keatlaretse Siamisang; Christopher G Williams; Leah Owen; Ezekiel Gwakuba; Tichaona Machiya; Tshepo Leeme; Hannah E Barton; Ronan Doyle ORCID logo; +5 more... Mark W Tenforde; Madisa Mine; David M Goldfarb; Margaret Mokomane; Joseph N Jarvis ORCID logo; (2022) Human Herpesvirus-6 Detection in Cerebrospinal Fluid on the BioFire FilmArray Meningitis/Encephalitis Panel in a High Human Immunodeficiency Virus-Prevalence African Setting. Open forum infectious diseases, 9 (7). ofac229-. ISSN 2328-8957 DOI: 10.1093/ofid/ofac229
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The prevalence and clinical relevance of human herpesvirus-6 (HHV-6) detection in cerebrospinal fluid (CSF) using multiplex polymerase chain reaction (PCR) testing in patients with suspected meningoencephalitis in high human immunodeficiency virus-prevalence African settings are not known. We describe the clinical and laboratory characteristics of 13 patients with HHV-6 CSF PCR positivity in Botswana.


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