Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.
;
Dylan M Williams ;
Alex J Walker ;
Ruth E Mitchell ;
Claire L Niedzwiedz ;
Tiffany C Yang;
Charlotte F Huggins;
Alex SF Kwong ;
Richard J Silverwood ;
Giorgio Di Gessa ;
+22 more...
Ruth CE Bowyer ;
Kate Northstone;
Bo Hou;
Michael J Green ;
Brian Dodgeon;
Katie J Doores ;
Emma L Duncan ;
Frances MK Williams ;
OpenSAFELY Collaborative;
Andrew Steptoe ;
David J Porteous ;
Rosemary RC McEachan;
Laurie Tomlinson ;
Ben Goldacre ;
Praveetha Patalay;
George B Ploubidis;
Srinivasa Vittal Katikireddi ;
Kate Tilling ;
Christopher T Rentsch ;
Nicholas J Timpson ;
Nishi Chaturvedi ;
Claire J Steves ;
(2022)
Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.
Nature Communications, 13 (1).
3528-.
DOI: 10.1038/s41467-022-30836-0
The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021. Proportions of presumed COVID-19 cases in LS reporting any symptoms for 12+ weeks ranged from 7.8% and 17% (with 1.2 to 4.8% reporting debilitating symptoms). Increasing age, female sex, white ethnicity, poor pre-pandemic general and mental health, overweight/obesity, and asthma were associated with prolonged symptoms in both LS and EHR data, but findings for other factors, such as cardio-metabolic parameters, were inconclusive.
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