Epidemiological and Immunological Features of Obesity and SARS-CoV-2
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Sameed M Siddiqui;
Stephanie Fischinger;
Yannic C Bartsch;
Michael de St. Aubin ;
Guohai Zhou;
Matthew J Gluck ;
Samuel Berger;
Justin Rhee;
Eric Petersen;
+22 more...
Benjamin Mormann;
Michael Loesche ;
Yiyuan Hu;
Zhilin Chen;
Jingyou Yu;
Makda Gebre;
Caroline Atyeo;
Matthew J Gorman;
Alex Lee Zhu;
John Burke;
Matthew Slein ;
Mohammad A Hasdianda ;
Guruprasad Jambaulikar;
Edward W Boyer;
Pardis C Sabeti;
Dan H Barouch;
Boris Julg;
Adam J Kucharski ;
Elon R Musk;
Douglas A Lauffenburger;
Galit Alter;
Anil S Menon ;
(2021)
Epidemiological and Immunological Features of Obesity and SARS-CoV-2.
Viruses, 13 (11).
p. 2235.
DOI: 10.3390/v13112235
<jats:p>Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.</jats:p>
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