Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
Stephanie LS Penetra;
Michele FB da Silva;
Paola Resende;
Anielle Pina-Costa;
Heloisa FP Santos;
Lusiele Guaraldo;
Guilherme A Calvet;
Maria Ogrzewalska;
Ighor Arantes;
Ketiuce Zukeram;
+17 more...
Mia F de Araújo;
Ana Beatriz Machado Lima;
Renata Serrano Lopes;
Larissa R Lira-Silva;
Isabella V Moraes;
Mayumi D Wakimoto;
Trevon L Fuller;
Claudia Raja Gabaglia;
Otávio M Espíndola;
Myrna C Bonaldo;
Cláudio Tadeu Daniel-Ribeiro;
Jimmy Whitworth 
;
Chris Smith ;
Karin Nielsen-Saines;
Alex Pauvolid-Correa;
Marilda M Siqueira;
Patricia Brasil;
(2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
International Journal of Infectious Diseases, 114.
pp. 58-61.
ISSN 1201-9712
DOI: 10.1016/j.ijid.2021.10.048
;
Chris Smith ;
Karin Nielsen-Saines;
Alex Pauvolid-Correa;
Marilda M Siqueira;
Patricia Brasil;
(2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
International Journal of Infectious Diseases, 114.
pp. 58-61.
ISSN 1201-9712
DOI: 10.1016/j.ijid.2021.10.048
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
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