Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda

Jan Pieter Koopman ORCID logo; Moses Egesa ORCID logo; AnneWajja; Moses Adriko ORCID logo; JacentNassuuna; Gyaviira Nkurunungi ORCID logo; Emmanuella Driciru ORCID logo; Gijsbertvan Willigen; Stephen Cose ORCID logo; MariaYazdanbakhsh; +5 more... PontianoKaleebu; NarcisKabatereine; EdridahTukahebwa; Meta Roestenberg ORCID logo; Alison M Elliott ORCID logo; (2019) Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda. AAS Open Research, 2. p. 17. DOI: 10.12688/aasopenres.12972.1
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<ns5:p>Schistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa, and a significant cause of morbidity; it is a priority for vaccine development. A controlled human infection model for <ns5:italic>Schistosoma mansoni</ns5:italic> (CHI-S) with potential to accelerate vaccine development has been developed among naïve volunteers in the Netherlands. Because responses both to infections and candidate vaccines are likely to differ between endemic and non-endemic settings, we propose to establish a CHI-S in Uganda where <ns5:italic>Schistosoma mansoni </ns5:italic>is endemic. As part of a “road-map” to this goal, we have undertaken a risk assessment. We identified risks related to importing of laboratory vector snails and schistosome strains from the Netherlands to Uganda; exposure to natural infection in endemic settings concurrently with CHI-S studies, and unfamiliarity of the community with the nature, risks and rationale for CHI. Mitigating strategies are proposed. With careful implementation of the latter, we believe that CHI-S can be implemented safely in Uganda. Our reflections are presented here to promote feedback and discussion.</ns5:p>



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