Vitamin D In Gambian Children With Discordant Tuberculosis Infection Status Despite Matched TB Exposure: A Case Control Study

Lisa Stockdale ORCID logo; BasilSambou; MuhamedSissoko; UzoEgere; Abdou KSillah; Beate Kampmann ORCID logo; Robin Basu Roy ORCID logo; (2021) Vitamin D In Gambian Children With Discordant Tuberculosis Infection Status Despite Matched TB Exposure: A Case Control Study. European Journal of Pediatrics. ISSN 0340-6199 DOI: 10.21203/rs.3.rs-484995/v1
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<jats:title>Abstract</jats:title> <jats:p>Using a matched case-control design we measured vitamin D levels in pairs of Gambian children with discordant infection status despite the same sleeping proximity to the same adult TB index case. Vitamin D levels were 2.05ng/mL higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-Exposed infected children (p=0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.</jats:p>


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