Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study
;
Rita Guerreiro;
Jose Bras;
David L Thomas;
Simon Mead;
Lieke Meeter;
Jessica Panman;
Rick van Minkelen;
Myriam Barandiaran;
Begoña Indakoetxea;
Alazne Gabilondo;
Mikel Tainta;
Ana Gorostidi;
Miren Zulaica;
Alina Díez;
Jorge Villanua;
Sergi Borrego‐Ecija;
Olives Jaume;
Albert Lladó;
Mircea Balasa;
Anna Antonell;
Nuria Bargallo;
Enrico Premi;
Stefano Gazzina;
Roberto Gasparotti;
Silvana Archetti;
Sandra Black;
Sara Mitchell;
Ekaterina Rogaeva;
Morris Freedman;
Ron Keren;
David Tang‐Wai;
Hakan Thonberg;
Linn Öijerstedt;
Christin Andersson;
Vesna Jelic;
Andrea Arighi;
Chiara Fenoglio;
Elio Scarpini;
Giorgio Fumagalli;
Thomas Cope;
Carolyn Timberlake;
Timothy Rittman;
Christen Shoesmith;
Robart Bartha;
Rosa Rademakers;
Carlo Wilke;
Hans‐Otto Karnarth;
Benjamin Bender;
Rose Bruffaerts;
Philip Vandamme;
Mathieu Vandenbulcke;
Catarina B Ferreira;
Gabriel Miltenberger;
Carolina Maruta;
Ana Verdelho;
Sónia Afonso;
Ricardo Taipa;
Paola Caroppo;
Giuseppe Di Fede;
Giorgio Giaccone;
Sara Prioni;
Veronica Redaelli;
Giacomina Rossi;
Pietro Tiraboschi;
Diana Duro;
Maria Rosario Almeida;
Miguel Castelo‐Branco;
Maria João Leitão;
Miguel Tabuas‐Pereira;
Beatriz Santiago;
Serge Gauthier;
Pedro Rosa‐Neto;
Michele Veldsman;
Paul Thompson;
Tobias Langheinrich;
Catharina Prix;
Tobias Hoegen;
Elisabeth Wlasich;
Sandra Loosli;
Sonja Schonecker;
Sarah Anderl‐Straub;
Jolina Lombardi;
Nuria Bargalló;
Alberto Benussi;
Valentina Cantoni;
Maxime Bertoux;
Anne Bertrand;
Alexis Brice;
Agnès Camuzat;
Olivier Colliot;
Sabrina Sayah;
Aurélie Funkiewiez;
Daisy Rinaldi;
Gemma Lombardi;
Benedetta Nacmias;
Dario Saracino;
Valentina Bessi;
Camilla Ferrari;
Marta Cañada;
Vincent Deramecourt;
Gregory Kuchcinski;
Thibaud Lebouvier;
Sebastien Ourselin;
Cristina Polito;
Adeline Rollin;
(2021)
Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 13 (1).
ISSN 2352-8729
DOI: 10.1002/dad2.12185
Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progran-ulin [GRN], and 73 microtubule-associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72-and MAPT-associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.
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