Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial.

Abdoulie Bojang; Sarah L Baines; Bully Camara; Romain Guerillot; Liam Donovan; Raquel Sánchez Marqués; Ousman Secka; Umberto D'Alessandro ORCID logo; Christian Bottomley ORCID logo; Benjamin P Howden; +1 more... Anna Roca ORCID logo; (2020) Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71 (12). pp. 3222-3225. ISSN 1058-4838 DOI: 10.1093/cid/ciaa609
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UNLABELLED: In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942.


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