High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
Seth C Inzaule;
Michael R Jordan;
George Bello;
Nellie Wadonda-Kabondo;
Salou Mounerou;
Innocent A Mbulli;
Sulaimon A Akanmu;
Adolfo Vubil;
Gillian Hunt;
Pontiano Kaleebu 
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+8 more...
Simangele Mthethwa-Hleza;
Janet Dzangare;
Patrick Njukeng;
Martina Penazzato;
Tobias F Rinke de Wit;
Susan H Eshleman;
Silvia Bertagnolio;
Infant HIV Drug Resistance Survey Team;
(2020)
High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
AIDS (London, England), 34 (10).
pp. 1567-1570.
ISSN 0269-9370
DOI: 10.1097/QAD.0000000000002580
;
+8 more...
Simangele Mthethwa-Hleza;
Janet Dzangare;
Patrick Njukeng;
Martina Penazzato;
Tobias F Rinke de Wit;
Susan H Eshleman;
Silvia Bertagnolio;
Infant HIV Drug Resistance Survey Team;
(2020)
High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
AIDS (London, England), 34 (10).
pp. 1567-1570.
ISSN 0269-9370
DOI: 10.1097/QAD.0000000000002580
: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.
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