The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19.

Marcos Pereira; Enny Paixão ORCID logo; Anete Trajman; Ramon Andrade de Souza; Marcio Santos da Natividade; Julia M Pescarini ORCID logo; Susan Martins Pereira; Florisneide Rodrigues Barreto; Ricardo Ximenes; Margareth Dalcomo; +4 more... Maria Yury Ichihara; Ceuci Nunes; Manoel Barral-Netto; Maurício L Barreto; (2020) The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19. RESPIRATORY RESEARCH, 21 (1). 178-. ISSN 1465-9921 DOI: 10.1186/s12931-020-01439-4
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Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.


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