Common variants associated with plasma triglycerides and risk for coronary artery disease.
Ron Do;
Cristen J Willer;
Ellen M Schmidt;
Sebanti Sengupta;
Chi Gao;
Gina M Peloso;
Stefan Gustafsson;
Stavroula Kanoni;
Andrea Ganna;
Jin Chen;
+253 more...
Martin L Buchkovich;
Samia Mora;
Jacques S Beckmann;
Jennifer L Bragg-Gresham;
Hsing-Yi Chang;
Ayşe Demirkan;
Heleen M Den Hertog;
Louise A Donnelly;
Georg B Ehret;
Tõnu Esko;
Mary F Feitosa;
Teresa Ferreira;
Krista Fischer;
Pierre Fontanillas;
Ross M Fraser;
Daniel F Freitag;
Deepti Gurdasani;
Kauko Heikkilä;
Elina Hyppönen;
Aaron Isaacs;
Anne U Jackson;
Asa Johansson;
Toby Johnson;
Marika Kaakinen;
Johannes Kettunen;
Marcus E Kleber;
Xiaohui Li;
Jian'an Luan;
Leo-Pekka Lyytikäinen;
Patrik KE Magnusson;
Massimo Mangino;
Evelin Mihailov;
May E Montasser;
Martina Müller-Nurasyid;
Ilja M Nolte;
Jeffrey R O'Connell;
Cameron D Palmer;
Markus Perola;
Ann-Kristin Petersen;
Serena Sanna;
Richa Saxena;
Susan K Service;
Sonia Shah;
Dmitry Shungin;
Carlo Sidore;
Ci Song;
Rona J Strawbridge;
Ida Surakka;
Toshiko Tanaka;
Tanya M Teslovich;
Gudmar Thorleifsson;
Evita G Van den Herik;
Benjamin F Voight;
Kelly A Volcik;
Lindsay L Waite;
Andrew Wong;
Ying Wu;
Weihua Zhang;
Devin Absher;
Gershim Asiki;
Inês Barroso;
Latonya F Been;
Jennifer L Bolton;
Lori L Bonnycastle;
Paolo Brambilla;
Mary S Burnett;
Giancarlo Cesana;
Maria Dimitriou;
Alex SF Doney;
Angela Döring;
Paul Elliott;
Stephen E Epstein;
Gudmundur Ingi Eyjolfsson;
Bruna Gigante;
Mark O Goodarzi;
Harald Grallert;
Martha L Gravito;
Christopher J Groves;
Göran Hallmans;
Anna-Liisa Hartikainen;
Caroline Hayward;
Dena Hernandez;
Andrew A Hicks;
Hilma Holm;
Yi-Jen Hung;
Thomas Illig;
Michelle R Jones;
Pontiano Kaleebu 
;
John JP Kastelein;
Kay-Tee Khaw;
Eric Kim;
Norman Klopp;
Pirjo Komulainen;
Meena Kumari;
Claudia Langenberg;
Terho Lehtimäki;
Shih-Yi Lin;
Jaana Lindström;
Ruth JF Loos;
François Mach;
Wendy L McArdle;
Christa Meisinger;
Braxton D Mitchell;
Gabrielle Müller;
Ramaiah Nagaraja;
Narisu Narisu;
Tuomo VM Nieminen;
Rebecca N Nsubuga;
Isleifur Olafsson;
Ken K Ong;
Aarno Palotie;
Theodore Papamarkou;
Cristina Pomilla;
Anneli Pouta;
Daniel J Rader;
Muredach P Reilly;
Paul M Ridker;
Fernando Rivadeneira;
Igor Rudan;
Aimo Ruokonen;
Nilesh Samani;
Hubert Scharnagl;
Janet Seeley ;
Kaisa Silander;
Alena Stančáková;
Kathleen Stirrups;
Amy J Swift;
Laurence Tiret;
Andre G Uitterlinden;
L Joost van Pelt;
Sailaja Vedantam;
Nicholas Wainwright;
Cisca Wijmenga;
Sarah H Wild;
Gonneke Willemsen;
Tom Wilsgaard;
James F Wilson;
Elizabeth H Young;
Jing Hua Zhao;
Linda S Adair;
Dominique Arveiler;
Themistocles L Assimes;
Stefania Bandinelli;
Franklyn Bennett;
Murielle Bochud;
Bernhard O Boehm;
Dorret I Boomsma;
Ingrid B Borecki;
Stefan R Bornstein;
Pascal Bovet;
Michel Burnier;
Harry Campbell;
Aravinda Chakravarti;
John C Chambers;
Yii-Der Ida Chen;
Francis S Collins;
Richard S Cooper;
John Danesh;
George Dedoussis;
Ulf de Faire;
Alan B Feranil;
Jean Ferrières;
Luigi Ferrucci;
Nelson B Freimer;
Christian Gieger;
Leif C Groop;
Vilmundur Gudnason;
Ulf Gyllensten;
Anders Hamsten;
Tamara B Harris;
Aroon Hingorani;
Joel N Hirschhorn;
Albert Hofman;
G Kees Hovingh;
Chao Agnes Hsiung;
Steve E Humphries;
Steven C Hunt;
Kristian Hveem;
Carlos Iribarren;
Marjo-Riitta Järvelin;
Antti Jula;
Mika Kähönen;
Jaakko Kaprio;
Antero Kesäniemi;
Mika Kivimaki;
Jaspal S Kooner;
Peter J Koudstaal;
Ronald M Krauss;
Diana Kuh;
Johanna Kuusisto;
Kirsten O Kyvik;
Markku Laakso;
Timo A Lakka;
Lars Lind;
Cecilia M Lindgren;
Nicholas G Martin;
Winfried März;
Mark I McCarthy;
Colin A McKenzie;
Pierre Meneton;
Andres Metspalu;
Leena Moilanen;
Andrew D Morris;
Patricia B Munroe;
Inger Njølstad;
Nancy L Pedersen;
Chris Power;
Peter P Pramstaller;
Jackie F Price;
Bruce M Psaty;
Thomas Quertermous;
Rainer Rauramaa;
Danish Saleheen;
Veikko Salomaa;
Dharambir K Sanghera;
Jouko Saramies;
Peter EH Schwarz;
Wayne H-H Sheu;
Alan R Shuldiner;
Agneta Siegbahn;
Tim D Spector;
Kari Stefansson;
David P Strachan;
Bamidele O Tayo;
Elena Tremoli;
Jaakko Tuomilehto;
Matti Uusitupa;
Cornelia M van Duijn;
Peter Vollenweider;
Lars Wallentin;
Nicholas J Wareham;
John B Whitfield;
Bruce HR Wolffenbuttel;
David Altshuler;
Jose M Ordovas;
Eric Boerwinkle;
Colin NA Palmer;
Unnur Thorsteinsdottir;
Daniel I Chasman;
Jerome I Rotter;
Paul W Franks;
Samuli Ripatti;
L Adrienne Cupples;
Manjinder S Sandhu;
Stephen S Rich;
Michael Boehnke;
Panos Deloukas;
Karen L Mohlke;
Erik Ingelsson;
Goncalo R Abecasis;
Mark J Daly;
Benjamin M Neale;
Sekar Kathiresan;
(2013)
Common variants associated with plasma triglycerides and risk for coronary artery disease.
NATURE GENETICS, 45 (11).
pp. 1345-1352.
ISSN 1061-4036
DOI: 10.1038/ng.2795
;
John JP Kastelein;
Kay-Tee Khaw;
Eric Kim;
Norman Klopp;
Pirjo Komulainen;
Meena Kumari;
Claudia Langenberg;
Terho Lehtimäki;
Shih-Yi Lin;
Jaana Lindström;
Ruth JF Loos;
François Mach;
Wendy L McArdle;
Christa Meisinger;
Braxton D Mitchell;
Gabrielle Müller;
Ramaiah Nagaraja;
Narisu Narisu;
Tuomo VM Nieminen;
Rebecca N Nsubuga;
Isleifur Olafsson;
Ken K Ong;
Aarno Palotie;
Theodore Papamarkou;
Cristina Pomilla;
Anneli Pouta;
Daniel J Rader;
Muredach P Reilly;
Paul M Ridker;
Fernando Rivadeneira;
Igor Rudan;
Aimo Ruokonen;
Nilesh Samani;
Hubert Scharnagl;
Janet Seeley ;
Kaisa Silander;
Alena Stančáková;
Kathleen Stirrups;
Amy J Swift;
Laurence Tiret;
Andre G Uitterlinden;
L Joost van Pelt;
Sailaja Vedantam;
Nicholas Wainwright;
Cisca Wijmenga;
Sarah H Wild;
Gonneke Willemsen;
Tom Wilsgaard;
James F Wilson;
Elizabeth H Young;
Jing Hua Zhao;
Linda S Adair;
Dominique Arveiler;
Themistocles L Assimes;
Stefania Bandinelli;
Franklyn Bennett;
Murielle Bochud;
Bernhard O Boehm;
Dorret I Boomsma;
Ingrid B Borecki;
Stefan R Bornstein;
Pascal Bovet;
Michel Burnier;
Harry Campbell;
Aravinda Chakravarti;
John C Chambers;
Yii-Der Ida Chen;
Francis S Collins;
Richard S Cooper;
John Danesh;
George Dedoussis;
Ulf de Faire;
Alan B Feranil;
Jean Ferrières;
Luigi Ferrucci;
Nelson B Freimer;
Christian Gieger;
Leif C Groop;
Vilmundur Gudnason;
Ulf Gyllensten;
Anders Hamsten;
Tamara B Harris;
Aroon Hingorani;
Joel N Hirschhorn;
Albert Hofman;
G Kees Hovingh;
Chao Agnes Hsiung;
Steve E Humphries;
Steven C Hunt;
Kristian Hveem;
Carlos Iribarren;
Marjo-Riitta Järvelin;
Antti Jula;
Mika Kähönen;
Jaakko Kaprio;
Antero Kesäniemi;
Mika Kivimaki;
Jaspal S Kooner;
Peter J Koudstaal;
Ronald M Krauss;
Diana Kuh;
Johanna Kuusisto;
Kirsten O Kyvik;
Markku Laakso;
Timo A Lakka;
Lars Lind;
Cecilia M Lindgren;
Nicholas G Martin;
Winfried März;
Mark I McCarthy;
Colin A McKenzie;
Pierre Meneton;
Andres Metspalu;
Leena Moilanen;
Andrew D Morris;
Patricia B Munroe;
Inger Njølstad;
Nancy L Pedersen;
Chris Power;
Peter P Pramstaller;
Jackie F Price;
Bruce M Psaty;
Thomas Quertermous;
Rainer Rauramaa;
Danish Saleheen;
Veikko Salomaa;
Dharambir K Sanghera;
Jouko Saramies;
Peter EH Schwarz;
Wayne H-H Sheu;
Alan R Shuldiner;
Agneta Siegbahn;
Tim D Spector;
Kari Stefansson;
David P Strachan;
Bamidele O Tayo;
Elena Tremoli;
Jaakko Tuomilehto;
Matti Uusitupa;
Cornelia M van Duijn;
Peter Vollenweider;
Lars Wallentin;
Nicholas J Wareham;
John B Whitfield;
Bruce HR Wolffenbuttel;
David Altshuler;
Jose M Ordovas;
Eric Boerwinkle;
Colin NA Palmer;
Unnur Thorsteinsdottir;
Daniel I Chasman;
Jerome I Rotter;
Paul W Franks;
Samuli Ripatti;
L Adrienne Cupples;
Manjinder S Sandhu;
Stephen S Rich;
Michael Boehnke;
Panos Deloukas;
Karen L Mohlke;
Erik Ingelsson;
Goncalo R Abecasis;
Mark J Daly;
Benjamin M Neale;
Sekar Kathiresan;
(2013)
Common variants associated with plasma triglycerides and risk for coronary artery disease.
NATURE GENETICS, 45 (11).
pp. 1345-1352.
ISSN 1061-4036
DOI: 10.1038/ng.2795
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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