Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.

Mark W Tenforde; Thandi Milton; Ikanyeng Rulaganyang; Charles Muthoga; Leabaneng Tawe; Tom Chiller; Gregory Greene; Alexander Jordan; Christopher G Williams; Leah Owen; +5 more... Tshepo B Leeme; Amber Boose; Julia Ngidi; Madisa Mine; Joseph N Jarvis ORCID logo; (2020) Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 72 (9). pp. 1635-1638. ISSN 1058-4838 DOI: 10.1093/cid/ciaa899
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Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.


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