<i>Anopheles stephensi</i> as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian <i>Plasmodium vivax</i> and <i>Plasmodium falciparum</i> isolates
;
Daniel Abebe Mekonnen;
Elifaged Hailemeskel;
Surafel K Tebeje;
Temesgen Tafesse;
Abrham Gashaw;
Tizita Tsegaye;
Tadele Emiru;
Kigozi Simon;
Eyuel Asemahegn Bogale;
Gedeon Yohannes;
Soriya Kedir;
Girma Shumie;
Senya Asfer Sabir;
Peter Mumba;
Dereje Dengela;
Jan H Kolaczinski;
Anne Wilson;
Thomas S Churcher;
Sheleme Chibsa;
Matthew Murphy;
Meshesha Balkew;
Seth Irish;
Chris Drakeley;
Endalamaw Gadisa;
Teun Bousema;
Fitsum G Tadesse;
(2020)
<i>Anopheles stephensi</i> as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian <i>Plasmodium vivax</i> and <i>Plasmodium falciparum</i> isolates.
bioRxiv.
DOI: 10.1101/2020.02.22.961284
<jats:title>Abstract</jats:title><jats:p><jats:italic>Anopheles stephensi</jats:italic>, an efficient Asian malaria vector, recently spread into the Horn of Africa and may increase malaria receptivity in African urban areas. We assessed occurrence, genetic complexity, blood meal source and infection status of <jats:italic>An. stephensi</jats:italic> in Awash Sebat Kilo town, Ethiopia. We used membrane feeding assays to assess competence of local <jats:italic>An. stephensi</jats:italic> to <jats:italic>P. vivax</jats:italic> and <jats:italic>P. falciparum</jats:italic> isolates from clinical patients. 75.3% of the examined waterbodies were infested with <jats:italic>An. stephensi</jats:italic> developmental stages that were genetically closely related to isolates from Djibouti and Pakistan. Both <jats:italic>P. vivax</jats:italic> and <jats:italic>P. falciparum</jats:italic> were detected in wild-caught adult <jats:italic>An. stephensi</jats:italic>. Local <jats:italic>An. stephensi</jats:italic> was more receptive to <jats:italic>P. vivax</jats:italic> compared to a colony of <jats:italic>An. arabiensis</jats:italic>. We conclude that <jats:italic>An. stephensi</jats:italic> is an established vector in this part of Ethiopia, highly permissive for local <jats:italic>P. vivax</jats:italic> and <jats:italic>P. falciparum</jats:italic> isolates and presents an important new challenge for malaria control.</jats:p><jats:sec><jats:title>Summary of the article</jats:title><jats:p><jats:italic>An. stephensi</jats:italic>, a metropolitan malaria vector that recently expanded to the Horn of African, was highly susceptible to local <jats:italic>P. falciparum</jats:italic> and <jats:italic>P. vivax</jats:italic> isolates from Ethiopia and may increase malariogenic potential of rapidly expanding urban settings in Africa.</jats:p></jats:sec>
-
picture_as_pdf - 2020.02.22.961284v1.full.pdf
-
subject - Published Version
-
copyright - Available under Copyright the author(s)