Outcomes in randomised controlled trials of multifocal lenses in cataract surgery: the case for development of a core outcome set.

Jennifer R Evans ORCID logo; Samantha R de Silva ORCID logo; Mohammed Ziaei ORCID logo; Varo Kirthi ORCID logo; Martin D Leyland; (2020) Outcomes in randomised controlled trials of multifocal lenses in cataract surgery: the case for development of a core outcome set. The British journal of ophthalmology, 104 (10). pp. 1345-1349. ISSN 0007-1161 DOI: 10.1136/bjophthalmol-2019-315410
Copy

BACKGROUND/AIMS: To describe and summarise the outcomes reported in randomised controlled trials of multifocal versus monofocal intraocular lenses in cataract surgery. METHODS: We identified all randomised controlled trials of multifocal versus monofocal lenses in a Cochrane review (last search date June 2016). We extracted and summarised data on all outcomes reported using the framework of domain, measurement, metric and method of aggregation. RESULTS: All studies collected data on distance and near visual acuity but there was considerable variation in the measures used and whether these outcomes were unaided or best corrected. Most studies reported final value measurements, rather than change from baseline. Approximately half of the studies reported data as a continuous measure only, one-third reported both continuous and categorical measures and a minority reported categorical measures only. There was little consensus as to cut-points. Although a majority of studies included one or more patient-reported outcome measures, none of the studies reported patient involvement in the choice of outcomes. CONCLUSION: The collection and analysis of data on outcome measures in studies of multifocal intraocular lenses in cataract surgery are complicated. As a result, there is considerable heterogeneity in collection and reporting in the medical literature. This makes it difficult to synthesise such data to provide robust estimates of effect and is a potential source of research waste. Investigators in this field must produce a core outcome set that is informed by patients' views and we propose an initial set of outcomes on which these could be based.

visibility_off picture_as_pdf

picture_as_pdf
Evans-etal-2020_Outcomes-in_randomised_controlled_trials.pdf
subject
Accepted Version
lock
Restricted to Repository staff only
Available under Creative Commons: NC-ND 3.0

Request Copy

Atom BibTeX OpenURL ContextObject in Span Multiline CSV OpenURL ContextObject Dublin Core Dublin Core MPEG-21 DIDL EndNote HTML Citation JSON MARC (ASCII) MARC (ISO 2709) METS MODS RDF+N3 RDF+N-Triples RDF+XML RIOXX2 XML Reference Manager Refer Simple Metadata ASCII Citation EP3 XML
Export

Downloads