Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.
Atis Muehlenbachs;
Olimpia de la Rosa Vázquez;
Daniel G Bausch 
;
Ilana J Schafer;
Christopher D Paddock;
Jean Paul Nyakio;
Papys Lame;
Eric Bergeron;
Andrea M McCollum;
Cynthia S Goldsmith;
+9 more...
Brigid C Bollweg;
Miriam Alía Prieto;
Robert Shongo Lushima;
Benoit Kebela Ilunga;
Stuart T Nichol;
Wun-Ju Shieh;
Ute Ströher;
Pierre E Rollin;
Sherif R Zaki;
(2017)
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.
The Journal of infectious diseases, 215 (1).
pp. 64-69.
ISSN 0022-1899
DOI: 10.1093/infdis/jiw206
;
Ilana J Schafer;
Christopher D Paddock;
Jean Paul Nyakio;
Papys Lame;
Eric Bergeron;
Andrea M McCollum;
Cynthia S Goldsmith;
+9 more...
Brigid C Bollweg;
Miriam Alía Prieto;
Robert Shongo Lushima;
Benoit Kebela Ilunga;
Stuart T Nichol;
Wun-Ju Shieh;
Ute Ströher;
Pierre E Rollin;
Sherif R Zaki;
(2017)
Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.
The Journal of infectious diseases, 215 (1).
pp. 64-69.
ISSN 0022-1899
DOI: 10.1093/infdis/jiw206
Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission.
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