Interferon-I: The Pièce de Résistance of HIV-1 Transmission?

Damien C Tully ORCID logo; Daniel TClaiborne; Todd MAllen; (2017) Interferon-I: The Pièce de Résistance of HIV-1 Transmission? Trends in microbiology, 25 (5). pp. 332-334. ISSN 0966-842X DOI: 10.1016/j.tim.2017.02.010
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Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons.
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