Adaptive from Innate: Human IFN-γ+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.

Abhishek Das ORCID logo; Kevin Rouault-Pierre ORCID logo; Shraddha Kamdar; Iria Gomez-Tourino; Kristie Wood; Ian Donaldson; Charles A Mein; Dominique Bonnet; Adrian C Hayday; Deena L Gibbons ORCID logo; (2017) Adaptive from Innate: Human IFN-γ+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults. The Journal of Immunology, 199 (5). pp. 1696-1705. ISSN 0022-1767 DOI: 10.4049/jimmunol.1700551
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We recently demonstrated that the major effector function of neonatal CD4+ T cells is to produce CXCL8, a prototypic cytokine of innate immune cells. In this article, we show that CXCL8 expression, prior to proliferation, is common in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies. This effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describing end-stage differentiation, such cells, whether isolated from neonates or adults, can further differentiate into IFN-γ-producing CD4+ T cells. Thus, the temporal transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellular level by the capacity of human innate-like CXCL8-producing CD4+ T cells to transition directly into Th1 cells.


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