Bacterial Autophagy: How to Take a Complement.

Vanessa Sancho-Shimizu; Serge Mostowy ORCID logo; (2018) Bacterial Autophagy: How to Take a Complement. Cell host & microbe, 23 (5). pp. 580-582. ISSN 1931-3128 DOI: 10.1016/j.chom.2018.04.010
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Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonomous immunity in the intestinal mucosa.

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