Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
Síle F Molloy;
John Bradley 
;
Natasha Karunaharan;
Muhammad Mputu;
Neil Stone;
Jacob Phulusa;
Chimwemwe Chawinga;
Kate Gaskell ;
Dalitso Segula;
Damien Ming;
+7 more...
Mary Peirse;
Duncan Chanda;
Shabir Lakhi;
Angela Loyse;
Cecilia Kanyama;
Robert S Heyderman;
Thomas S Harrison;
(2018)
Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
AIDS (London, England), 32 (15).
pp. 2259-2261.
ISSN 0269-9370
DOI: 10.1097/QAD.0000000000001961
;
Natasha Karunaharan;
Muhammad Mputu;
Neil Stone;
Jacob Phulusa;
Chimwemwe Chawinga;
Kate Gaskell ;
Dalitso Segula;
Damien Ming;
+7 more...
Mary Peirse;
Duncan Chanda;
Shabir Lakhi;
Angela Loyse;
Cecilia Kanyama;
Robert S Heyderman;
Thomas S Harrison;
(2018)
Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
AIDS (London, England), 32 (15).
pp. 2259-2261.
ISSN 0269-9370
DOI: 10.1097/QAD.0000000000001961
: We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: -28 to 46 ms) in the fluconazole treatment group and -12.6 ms (IQR: -39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.
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picture_as_pdf - Effect of oral fluconazole 1200_GREEN AAM.pdf
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subject - Accepted Version
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- Available under Creative Commons: NC-ND 3.0
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