Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome.
Enny S Paixao 
;
Wei-Yee Leong;
Laura C Rodrigues;
Annelies Wilder-Smith ;
(2018)
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome.
Open forum infectious diseases, 5 (4).
ofy073-.
ISSN 2328-8957
DOI: 10.1093/ofid/ofy073
;
Wei-Yee Leong;
Laura C Rodrigues;
Annelies Wilder-Smith ;
(2018)
Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome.
Open forum infectious diseases, 5 (4).
ofy073-.
ISSN 2328-8957
DOI: 10.1093/ofid/ofy073
To investigate to what extent asymptomatic vs symptomatic prenatal Zika virus infections contribute to birth defects, we identified 3 prospective and 8 retrospective studies. The ratio varied greatly in the retrospective studies, most likely due to recruitment and recall bias. The prospective studies revealed a ratio of 1:1 for asymptomatic vs symptomatic maternal Zika infections resulting in adverse fetal outcomes.
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