Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Jayaram Vijayakrishnan;
James Studd 
;
Peter Broderick ;
Ben Kinnersley ;
Amy Holroyd;
Philip J Law ;
Rajiv Kumar;
James M Allan;
Christine J Harrison;
Anthony V Moorman;
+30 more...
Ajay Vora;
Eve Roman;
Sivaramakrishna Rachakonda;
Sally E Kinsey;
Eamonn Sheridan;
Pamela D Thompson;
Julie A Irving;
Rolf Koehler;
Per Hoffmann;
Markus M Nöthen;
Stefanie Heilmann-Heimbach;
Karl-Heinz Jöckel;
Douglas F Easton ;
Paul DP Pharaoh ;
Alison M Dunning;
Julian Peto ;
Frederico Canzian ;
Anthony Swerdlow;
Rosalind A Eeles ;
ZSofia Kote-Jarai;
Kenneth Muir ;
Nora Pashayan ;
PRACTICAL Consortium;
Mel Greaves;
Martin Zimmerman;
Claus R Bartram;
Martin Schrappe;
Martin Stanulla;
Kari Hemminki;
Richard S Houlston;
(2018)
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nature communications, 9 (1).
1340-.
ISSN 2041-1723
DOI: 10.1038/s41467-018-03178-z
;
Peter Broderick ;
Ben Kinnersley ;
Amy Holroyd;
Philip J Law ;
Rajiv Kumar;
James M Allan;
Christine J Harrison;
Anthony V Moorman;
+30 more...
Ajay Vora;
Eve Roman;
Sivaramakrishna Rachakonda;
Sally E Kinsey;
Eamonn Sheridan;
Pamela D Thompson;
Julie A Irving;
Rolf Koehler;
Per Hoffmann;
Markus M Nöthen;
Stefanie Heilmann-Heimbach;
Karl-Heinz Jöckel;
Douglas F Easton ;
Paul DP Pharaoh ;
Alison M Dunning;
Julian Peto ;
Frederico Canzian ;
Anthony Swerdlow;
Rosalind A Eeles ;
ZSofia Kote-Jarai;
Kenneth Muir ;
Nora Pashayan ;
PRACTICAL Consortium;
Mel Greaves;
Martin Zimmerman;
Claus R Bartram;
Martin Schrappe;
Martin Stanulla;
Kari Hemminki;
Richard S Houlston;
(2018)
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nature communications, 9 (1).
1340-.
ISSN 2041-1723
DOI: 10.1038/s41467-018-03178-z
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
-
picture_as_pdf - Genome-wide-association-study-identifies-susceptibility-loci-for-B-cell-childhood-acute-lymphoblastic-leukemia.pdf
-
subject - Published Version
-
- Available under Creative Commons: 3.0
Downloads