Mental disorders and drug/alcohol use in patients commencing extensively drug-resistant tuberculosis treatment.

J Scuffell; D Boccia ORCID logo; F Garcia Velarde; SR Leon; G Raviola; L Lecca; JT Galea; (2017) Mental disorders and drug/alcohol use in patients commencing extensively drug-resistant tuberculosis treatment. Public health action, 7 (3). pp. 237-239. ISSN 2220-8372 DOI: 10.5588/pha.17.0044
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Mental disorders and alcohol/drug use worsen treatment outcomes for multidrug-resistant tuberculosis (TB), but data are lacking for extensively drug-resistant (XDR) TB. We investigated the association of baseline mental disorders and alcohol/drug use on XDR-TB treatment outcomes in a retrospective study of 53 XDR-TB Peruvian patients during 2010-2012. Logistic regression estimated the odds ratios for unfavourable XDR-TB treatment outcomes. Overall treatment success was 25%. Mental disorders and drug/alcohol use were found in respectively 22.4% and 20.4% of patients; neither were associated with unfavourable treatment outcomes. Future research should explore the relationship between mental health and drug/alcohol use in XDR-TB treatment outcomes.


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