Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Yoshio Nakatani;
Helen K Opel-Reading;
Matthias Merker;
Diana Machado;
Sönke Andres;
S Siva Kumar;
Danesh Moradigaravand;
Francesc Coll 
;
João Perdigão;
Isabel Portugal;
+19 more...
Thomas Schön;
Dina Nair;
KR Uma Devi;
Thomas A Kohl;
Patrick Beckert;
Taane G Clark ;
Gugu Maphalala;
Derrick Khumalo;
Roland Diel;
Kadri Klaos;
Htin Lin Aung ;
Gregory M Cook;
Julian Parkhill ;
Sharon J Peacock;
Soumya Swaminathan;
Miguel Viveiros;
Stefan Niemann;
Kurt L Krause;
Claudio U Köser ;
(2017)
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Antimicrobial agents and chemotherapy, 61 (12).
ISSN 0066-4804
DOI: 10.1128/AAC.01575-17
;
João Perdigão;
Isabel Portugal;
+19 more...
Thomas Schön;
Dina Nair;
KR Uma Devi;
Thomas A Kohl;
Patrick Beckert;
Taane G Clark ;
Gugu Maphalala;
Derrick Khumalo;
Roland Diel;
Kadri Klaos;
Htin Lin Aung ;
Gregory M Cook;
Julian Parkhill ;
Sharon J Peacock;
Soumya Swaminathan;
Miguel Viveiros;
Stefan Niemann;
Kurt L Krause;
Claudio U Köser ;
(2017)
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Antimicrobial agents and chemotherapy, 61 (12).
ISSN 0066-4804
DOI: 10.1128/AAC.01575-17
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
-
picture_as_pdf - Role of alanine racemase mutations_GREEN AAM.pdf
-
subject - Accepted Version
-
- Available under Creative Commons: NC-ND 3.0
Downloads