Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies.

CP Farrington; MJ Firth; LH Moulton; H Ravn; PK Andersen; S Evans ORCID logo; Working Group on Non-specific Effects of Vaccines; (2009) Epidemiological studies of the non-specific effects of vaccines: II--methodological issues in the design and analysis of cohort studies. Tropical medicine & international health, 14 (9). pp. 977-985. ISSN 1360-2276 DOI: 10.1111/j.1365-3156.2009.02302.x
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We review sources of bias which can affect non-randomized cohort studies of non-specific effects of vaccines on child mortality. Using examples from the literature on non-specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.

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