A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.

Mahamadou Diakite; Taane G Clark ORCID logo; Sarah Auburn; Susana Campino ORCID logo; Andrew E Fry; Angela Green; Andrew P Morris; Anna Richardson; Muminatou Jallow; Fatou Sisay-Joof; +3 more... Margaret Pinder; Dominic P Kwiatkowski; Kirk A Rockett; (2009) A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility. Human genetics, 125 (1). pp. 105-109. ISSN 0340-6717 DOI: 10.1007/s00439-008-0597-2
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The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with 11 haplotype tagging-polymorphisms for 11 MHC class III candidate genes, including TNF, lymphotoxin alpha (LTA), allograft inflammatory factor 1 (AIF1), and HLA-B associated transcript 2 (BAT2). An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria.

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