The change in blood glucose levels in tuberculosis patients before and during anti-tuberculosis treatment in China.

Yan Lin; Yanli Yuan; Xin Zhao; Jianmu Liu; Linxi Qiu; Xiaoxin He; Yunlong Bai; Bo Li; Zhong Zeng; Guangxu Yang; +5 more... Xu Meng; Chunyu Yuan; Hailun Zheng; Wanli Kang; Anthony D Harries; (2017) The change in blood glucose levels in tuberculosis patients before and during anti-tuberculosis treatment in China. Global health action, 10 (1). 1289737-. ISSN 1654-9716 DOI: 10.1080/16549716.2017.1289737
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OBJECTIVE: We aimed to observe (i) changes in fasting blood glucose (FBG) in tuberculosis (TB) patients before and during anti-TB treatment, (ii) whether FBG levels were stable or unstable and (iii) baseline characteristics associated with an unstable FBG. METHOD: TB patients consecutively attended six clinics or hospitals. FBG measurements were made at months 0, 2 and 6. Data analysis was performed using the chi-square test and multivariate logistic regression. RESULTS: Of 232 patients without diabetes mellitus (DM) whose initial FBG < 6.1 mmol/L, over 90% maintained FBG < 6.1 mmol/L during treatment and no patient developed DM. Of 17 patients without DM and initial FBG between 6.1 and 6.9 mmol/L, over half had FBG < 6.1 mmol/L during treatment and no patient had DM at the end of treatment. Eight DM patients with already known DM had their FBG controlled at < 7.0 mmol/L during treatment. There were 13 DM patients newly diagnosed with FBG ≥ 7.0 mmol/L, and 69% continued to have FBG ≥ 7.0 mmol/L. After adjustment for confounding, the odds for an unstable FBG were higher for HIV-positive status, already having DM, smoking and coming to hospitals rather than clinics. CONCLUSION: TB patients who do not have DM based on FBG measurements do not develop DM during anti-TB treatment. Those newly diagnosed with DM on screening in general maintain their DM status with high FBG and need to be better managed.


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