Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
;
Leandro M Colli;
Peng Li;
Joshua N Sampson;
Behnoush Abedi-Ardekani;
Celine Besse;
Helene Blanche;
Anne Boland;
Laurie Burdette;
Amelie Chabrier;
Geoffroy Durand;
Florence Le Calvez-Kelm;
Egor Prokhortchouk;
Nivonirina Robinot;
Konstantin G Skryabin;
Magdalena B Wozniak;
Meredith Yeager;
Gordana Basta-Jovanovic;
Zoran Dzamic;
Lenka Foretova;
Ivana Holcatova;
Vladimir Janout;
Dana Mates;
Anush Mukeriya;
Stefan Rascu;
David Zaridze;
Vladimir Bencko;
Cezary Cybulski;
Eleonora Fabianova;
Viorel Jinga;
Jolanta Lissowska;
Jan Lubinski;
Marie Navratilova;
Peter Rudnai;
Neonila Szeszenia-Dabrowska;
Simone Benhamou;
Geraldine Cancel-Tassin;
Olivier Cussenot;
Laura Baglietto;
Heiner Boeing;
Kay-Tee Khaw;
Elisabete Weiderpass;
Borje Ljungberg;
Raviprakash T Sitaram;
Fiona Bruinsma;
Susan J Jordan;
Gianluca Severi;
Ingrid Winship;
Kristian Hveem;
Lars J Vatten;
Tony Fletcher ;
Kvetoslava Koppova;
Susanna C Larsson ;
Alicja Wolk ;
Rosamonde E Banks;
Peter J Selby;
Douglas F Easton;
Paul Pharoah ;
Gabriella Andreotti;
Laura E Beane Freeman;
Stella Koutros;
Demetrius Albanes;
Satu Männistö;
Stephanie Weinstein;
Peter E Clark;
Todd L Edwards ;
Loren Lipworth;
Susan M Gapstur;
Victoria L Stevens;
Hallie Carol;
Matthew L Freedman;
Mark M Pomerantz;
Eunyoung Cho;
Peter Kraft;
Mark A Preston;
Kathryn M Wilson;
J Michael Gaziano;
Howard D Sesso;
Amanda Black;
Neal D Freedman;
Wen-Yi Huang;
John G Anema;
Richard J Kahnoski;
Brian R Lane;
Sabrina L Noyes;
David Petillo;
Bin Tean Teh;
Ulrike Peters;
Emily White;
Garnet L Anderson;
Lisa Johnson;
Juhua Luo;
Julie Buring;
I-Min Lee;
Wong-Ho Chow;
Lee E Moore;
Christopher Wood;
Timothy Eisen;
Marc Henrion;
James Larkin;
Poulami Barman;
Bradley C Leibovich;
Toni K Choueiri;
G Mark Lathrop;
Nathaniel Rothman;
Jean-Francois Deleuze;
James D McKay;
Alexander S Parker;
Xifeng Wu;
Richard S Houlston;
Paul Brennan;
Stephen J Chanock;
(2017)
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Nature communications, 8 (1).
15724-.
ISSN 2041-1723
DOI: 10.1038/ncomms15724
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
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