Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin.

John Bradley ORCID logo; Aurore Ogouyèmi-Hounto; Sylvie Cornélie; Jacob Fassinou; Yolande Sissinto Savi de Tove; Adicath Adéola Adéothy; Filémon T Tokponnon; Patrick Makoutode; Alioun Adechoubou; Thibaut Legba; +7 more... Telesphore Houansou; Dorothée Kinde-Gazard; Martin C Akogbeto; Achille Massougbodji; Tessa Bellamy Knox; Martin Donnelly; Immo Kleinschmidt; (2017) Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin. Malaria journal, 16 (1). 225-. ISSN 1475-2875 DOI: 10.1186/s12936-017-1873-1
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BACKGROUND: Malaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa. METHODS: In 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children. RESULTS: Children who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999). CONCLUSIONS: LLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.


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