Genetic loci influencing kidney function and chronic kidney disease.
John C Chambers;
Weihua Zhang;
Graham M Lord;
Pim van der Harst;
Debbie A Lawlor;
Joban S Sehmi;
Daniel P Gale;
Mark N Wass;
Kourosh R Ahmadi;
Stephan JL Bakker;
+84 more...
Jacqui Beckmann;
Henk JG Bilo;
Murielle Bochud;
Morris J Brown;
Mark J Caulfield;
John MC Connell;
H Terence Cook;
Ioana Cotlarciuc;
George Davey Smith;
Ranil de Silva;
Guohong Deng;
Olivier Devuyst;
Lambert D Dikkeschei;
Nada Dimkovic;
Mark Dockrell;
Anna Dominiczak;
Shah Ebrahim;
Thomas Eggermann;
Martin Farrall;
Luigi Ferrucci;
Jurgen Floege;
Nita G Forouhi;
Ron T Gansevoort;
Xijin Han;
Bo Hedblad;
Jaap J Homan van der Heide;
Bouke G Hepkema;
Maria Hernandez-Fuentes;
Elina Hypponen;
Toby Johnson;
Paul E de Jong;
Nanne Kleefstra;
Vasiliki Lagou;
Marta Lapsley;
Yun Li;
Ruth JF Loos;
Jian'an Luan;
Karin Luttropp;
Céline Maréchal;
Olle Melander;
Patricia B Munroe;
Louise Nordfors;
Afshin Parsa;
Leena Peltonen;
Brenda W Penninx;
Esperanza Perucha;
Anneli Pouta;
Inga Prokopenko;
Paul J Roderick;
Aimo Ruokonen;
Nilesh J Samani;
Serena Sanna;
Martin Schalling;
David Schlessinger;
Georg Schlieper;
Marc AJ Seelen;
Alan R Shuldiner;
Marketa Sjögren;
Johannes H Smit;
Harold Snieder;
Nicole Soranzo;
Timothy D Spector;
Peter Stenvinkel;
Michael JE Sternberg;
Ramasamyiyer Swaminathan;
Toshiko Tanaka;
Lielith J Ubink-Veltmaat;
Manuela Uda;
Peter Vollenweider;
Chris Wallace;
Dawn Waterworth;
Klaus Zerres;
Gerard Waeber;
Nicholas J Wareham;
Patrick H Maxwell;
Mark I McCarthy;
Marjo-Riitta Jarvelin;
Vincent Mooser;
Goncalo R Abecasis;
Liz Lightstone;
James Scott;
Gerjan Navis;
Paul Elliott;
Jaspal S Kooner;
(2010)
Genetic loci influencing kidney function and chronic kidney disease.
Nature genetics, 42 (5).
pp. 373-375.
ISSN 1061-4036
DOI: 10.1038/ng.566
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
| Item Type | Article |
|---|---|
| ISI | 277179500005 |
Explore Further
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748585 (OA Location)
- 10.1038/ng.566 (DOI)
- 20383145 (PubMed)