New loci associated with kidney function and chronic kidney disease.
;
Anita Brandstätter;
Barbara Kollerits;
Lyudmyla Kedenko;
Reedik Mägi;
Michael Stumvoll;
Peter Kovacs;
Mladen Boban;
Susan Campbell;
Karlhans Endlich;
Henry Völzke;
Heyo K Kroemer;
Matthias Nauck;
Uwe Völker;
Ozren Polasek;
Veronique Vitart;
Sunita Badola;
Alexander N Parker;
Paul M Ridker;
Sharon LR Kardia;
Stefan Blankenberg;
Yongmei Liu;
Gary C Curhan;
Andre Franke;
Thierry Rochat;
Bernhard Paulweber;
Inga Prokopenko;
Wei Wang;
Vilmundur Gudnason;
Alan R Shuldiner;
Josef Coresh;
Reinhold Schmidt;
Luigi Ferrucci;
Michael G Shlipak;
Cornelia M van Duijn;
Ingrid Borecki;
Bernhard K Krämer;
Igor Rudan;
Ulf Gyllensten;
James F Wilson;
Jacqueline C Witteman;
Peter P Pramstaller;
Rainer Rettig;
Nick Hastie;
Daniel I Chasman;
WH Kao;
Iris M Heid;
Caroline S Fox;
(2010)
New loci associated with kidney function and chronic kidney disease.
Nature genetics, 42 (5).
pp. 376-384.
ISSN 1061-4036
DOI: 10.1038/ng.568
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.