New insights into an X-traordinary viral protein.
Torsten Schaller;
Hélène Bauby;
Stéphane Hué;
Michael H Malim;
Caroline Goujon;
(2014)
New insights into an X-traordinary viral protein.
Frontiers in microbiology, 5 (APR).
126-.
ISSN 1664-302X
DOI: 10.3389/fmicb.2014.00126
Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.
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