Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Hayley Crawford;
Julia G Prado;
Alasdair Leslie;
Stéphane Hué;
Isobella Honeyborne;
Sharon Reddy;
Mary van der Stok;
Zenele Mncube;
Christian Brander;
Christine Rousseau;
+9 more...
James I Mullins;
Richard Kaslow;
Paul Goepfert;
Susan Allen;
Eric Hunter;
Joseph Mulenga;
Photini Kiepiela;
Bruce D Walker;
Philip JR Goulder;
(2007)
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Journal of virology, 81 (15).
pp. 8346-8351.
ISSN 0022-538X
DOI: 10.1128/JVI.00465-07
HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia.
| Item Type | Article |
|---|---|
| ISI | 248027400053 |