pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Colin J Sutherland 
;
Paul Lansdell;
Mandy Sanders;
Julian Muwanguzi;
Donelly A van Schalkwyk ;
Harparkash Kaur;
Debbie Nolder;
Julie Tucker;
Hayley M Bennett;
Thomas D Otto;
+5 more...
Matthew Berriman;
Trupti A Patel;
Roderick Lynn;
Effrossyni Gkrania-Klotsas;
Peter L Chiodini;
(2017)
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Antimicrobial agents and chemotherapy, 61 (3).
ISSN 0066-4804
DOI: 10.1128/AAC.02382-16
;
Paul Lansdell;
Mandy Sanders;
Julian Muwanguzi;
Donelly A van Schalkwyk ;
Harparkash Kaur;
Debbie Nolder;
Julie Tucker;
Hayley M Bennett;
Thomas D Otto;
+5 more...
Matthew Berriman;
Trupti A Patel;
Roderick Lynn;
Effrossyni Gkrania-Klotsas;
Peter L Chiodini;
(2017)
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Antimicrobial agents and chemotherapy, 61 (3).
ISSN 0066-4804
DOI: 10.1128/AAC.02382-16
We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.
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