Early impact of rotavirus vaccination in a large paediatric hospital in the UK.
D Hungerford;
JM Read;
RP Cooke;
R Vivancos;
M Iturriza-Gómara;
DJ Allen;
N French;
N Cunliffe;
(2015)
Early impact of rotavirus vaccination in a large paediatric hospital in the UK.
Technical Report.
Elsevier.
DOI: 10.1016/j.jhin.2015.12.010
The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.
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