5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population.
Tom Power;
Robert Stewart;
Marie-Laure Ancelin;
Isabelle Jaussent;
Alain Malafosse;
Karen Ritchie;
(2010)
5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population.
Neurobiology of aging, 31 (5).
pp. 886-887.
ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2008.06.006
Modification of the effect of life events on risk of depression by a polymorphism in the serotonin transporter gene promoter (5-HTTLPR) has been reported in child, adolescent, adult and elderly populations. Replication attempted on data collected from 1421 individuals aged 65 and over from a French community study provided no evidence of a similar modifying effect. In the only analysis known to the authors to be carried out in an exclusively elderly, European population, this null finding remained consistent after restriction of analysis to prevalent or incident cases.
| Item Type | Article |
|---|---|
| Keywords | Life stress, Serotonin transporter, 5-HTTLPR, Depression, Gene�environment interaction, Old age, Aged, Aged, 80 and over, Aging, genetics, Alleles, Depression, genetics, Depressive Disorder, diagnosis, genetics, European Continental Ancestry Group, genetics, Female, France, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Life Change Events, Male, Promoter Regions, Genetic, genetics, Questionnaires, Serotonin Plasma Membrane Transport Proteins, genetics, Gene�environment interaction, Gene�environment interaction, Gene–environment interaction |
| ISI | 276221600019 |
| Official URL | http://linkinghub.elsevier.com/retrieve/pii/S01974... |