Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

Paul M O'Neill; Richard K Amewu; Gemma L Nixon; Fatima Bousejra ElGarah; Mathirut Mungthin; James Chadwick; Alison E Shone; Livia Vivas; Hollie Lander; Victoria Barton; +9 more... Sant Muangnoicharoen; Patrick G Bray; Jill Davies; B Kevin Park; Sergio Wittlin; Reto Brun; Michael Preschel; Kesheng Zhang; Stephen A Ward; (2010) Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie (International ed in English), 49 (33). pp. 5693-5697. ISSN 1433-7851 DOI: 10.1002/anie.201001026