Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile.

Andrew N Phillips; Valentina Cambiano; Fumiyo Nakagawa; Deborah Ford; Tsitsi Apollo; Joseph Murungu; Christine Rousseau; Geoff Garnett; Peter Ehrenkranz; Loveleen Bansi-Matharu; +4 more... Lara Vojnov; Zachary Katz; Rosanna Peeling ORCID logo; Paul Revill; (2016) Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile. Open forum infectious diseases, 3 (3). ofw161-. ISSN 2328-8957 DOI: 10.1093/ofid/ofw161
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Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic and ART program in Zimbabwe and found that the attributes of a viral load testing approach that are most influential for cost effectiveness are avoidance of a high proportion of failed tests or results not received, use of an approach that best facilitates retention on ART, and the ability to facilitate greater use of differentiated care, including through expanding coverage of testing availability.


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