Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Thorsten Thye;
Fredrik O Vannberg;
Sunny H Wong;
Ellis Owusu-Dabo;
Ivy Osei;
John Gyapong;
Giorgio Sirugo;
Fatou Sisay-Joof;
Anthony Enimil;
Margaret A Chinbuah;
+23 more...
Sian Floyd 
;
David K Warndorff;
Lifted Sichali;
Simon Malema;
Amelia C Crampin ;
Bagrey Ngwira;
Yik Y Teo;
Kerrin Small;
Kirk Rockett;
Dominic Kwiatkowski;
Paul E Fine;
Philip C Hill;
Melanie Newport;
Christian Lienhardt;
Richard A Adegbola;
Tumani Corrah;
Andreas Ziegler;
African TB Genetics Consortium;
Wellcome Trust Case Control Consortium;
Andrew P Morris;
Christian G Meyer;
Rolf D Horstmann;
Adrian VS Hill;
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
;
David K Warndorff;
Lifted Sichali;
Simon Malema;
Amelia C Crampin ;
Bagrey Ngwira;
Yik Y Teo;
Kerrin Small;
Kirk Rockett;
Dominic Kwiatkowski;
Paul E Fine;
Philip C Hill;
Melanie Newport;
Christian Lienhardt;
Richard A Adegbola;
Tumani Corrah;
Andreas Ziegler;
African TB Genetics Consortium;
Wellcome Trust Case Control Consortium;
Andrew P Morris;
Christian G Meyer;
Rolf D Horstmann;
Adrian VS Hill;
(2010)
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
Nature genetics, 42 (9).
pp. 739-741.
ISSN 1061-4036
DOI: 10.1038/ng.639
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
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